External factors for allergy development

Potential supervisors: 
Research groups/keywords: 
Description: 

Allergies are a common phenomenon both for adults as well as for children. During the last decades, food allergies have increased largely, for example, self-reported peanut allergies in US children doubled from 1997 to 2002 (Sicherer, 2003). The exact mechanisms leading to an allergy are not yet fully understood, however, a set of aspects, including genetic traits and environmental factors influence their development. Therefore, the guidelines on how to avoid allergies in children shifted from avoidance to early contacts with the allergenic food to induce tolerance (Caffarelli, 2018). This thesis aims to analyze publicly available data on allergies with respect to a relationship between allergies and external factors, such as early introduction of the allergenic food.

Data is available, for example, in the “Enquiring About Tolerance” trial from the UK Food Standards Agency (https://data.food.gov.uk/ ).

Examples for research questions

  • Predict allergies based on the consumption of allergens at different times in early childhood.
  • Analyze allergies: Are some more affected by the early introduction to the allergens than others? Are some time frames more important?

Requirements

  • Studies in computer science or related.
  • Courses in machine learning
  • Programming skills
  • The project is suitable for 1-2 students, preferred 2.

References

Caffarelli et al. (2018) Solid Food Introduction and the Development of Food Allergies. Nutrients 10(11)

Sicherer  et al. (2003) Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study. J Allergy Clin Immunol 112(6):1203-7

Date range: 
October, 2021 to October, 2023